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Further studies in different cancers, including acute and chronic leukemias, mantle cell lymphoma, hairy cell leukemia, mucosa associated lymphoid tissue (MALT)-type lymphoma, and Langerhans cell histiocytosis have been done with combination therapies in both pediatric and adult populations (144148)

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Although numerous preclinical studies have shown that iron chelators such as deferoxamine (DFO), deferiprone (DFP), and PBT2 effectively mitigate brain iron overload, reduce amyloid burden, and improve cognition in AD models, translation to the clinic has proven challenging