A non-canonical mechanism of Nrf2 activation by autophagy deficiency due to direct interaction between Keap1 and p62 has been recently proposed [56,57]
If you are into chemistry (if not, we understand, just skip this paragraph), the reason is that electrolytes (you know, the Na+ and Cl- ions) screen the electrostatic repulsion between the head groups of ionic surfactants and thus support the formation of long shaped micelles (instead of spherical ones) that entangle like spaghetti, and viola, a gel is formed
For example, lactylation of apolipoprotein C-II (APOC2) at lysine 70 prevents its degradation and stabilizes the protein, leading to free fatty acid (FFA) release and accumulation in regulatory T cells
However, it is vital to the study
These fractional units are genuinely difficult to measure on standard syringes
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