This study was supported in part by the Grant-in-Aid for Scientific Research (C) (26460302 to Y.I.) and Innovative Areas (26670453 and 16K15182 to T.Y.) from Japan Society of the Promotion of Science, and grants from Japan Diabetes Foundation to Y.I
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These observations suggest that besides modulating HSCs homeostasis, GPX4 may also have an important role in regulating monocyte and macrophage functions
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However, its non-selective agonist action raises safety concerns, notably the potential risk of renal infarction