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Dietary composition, meal timing, exercise, and sleep quality all significantly influence this metabolic pathway

Injection of GLP-1 directly into the central nucleus of the amygdala (CeA) of rats results in CTA (Kinzig et al., 2002) whereas injection into the PVN reduces food intake without eliciting CTA (McMahon and Wellman, 1998)

We then laparatomized the rats for the portal vein, inferior vena caval and abdominal aortal pressure recordings

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Unlike older medications that only target the GLP-1 receptor, tirzepatide also activates the GIP receptor