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Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gutintestinal permeability

That makes it particularly relevant in our modern world, where exposure to pollutants, stress, and processed foods is constant

doi: 10.1126/science.abd0237 33 PathareGRDecoutAGlckSCavadiniSMakashevaKHoviusRet al

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established an in vitro rabbit corneal tissue model of PAO exposure (5 or 10 g) over a duration of 3, 5, and 10 minutes, followed by treatment with NAC

Here's the general trajectory