Insulin is a hormone that helps sugar move from the blood into the cells, where it can be used for energy
391 GLP-1 and GLP-1 analogs exert their effects on food intake and body weight through a myriad of neural substrates, encompassing several hypothalamic nuclei (including the arcuate nucleus of the hypothalamus, periventricular hypothalamus, and lateral hypothalamic area), hindbrain nuclei (such as the parabrachial nucleus and medial nucleus tractus solitarius), the ventral subregion of the hippocampus (vHP), and nuclei embedded within the mesolimbic reward circuitry (including the ventral tegmental area, VTA, and nucleus accumbens, NAc)
Gastroenterology 1993
Therefore, the increased risk of NLRP3-associated autoinflammatory diseases should be considered in the clinical use of drugs such as pioglitazone that target MPC (61)
Lilly is evaluating the safety and efficacy of orforglipron in patients with both Type 2 diabetes as well as obesity or overweight
In terms of side effects and tolerability, the advantage goes to Melanotan-1
