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Despite the limitations of real-world observational studiesincluding the absence of randomization, control for confounding variables, and inability to establish causalityresearches offer confidence regarding the pancreatic safety profiles of GLP-1 RAs [55,61]

In terms of oral health effects, studies highlight both potential benefits, such as reduced gum inflammation, and detrimental effects, including weakening of enamel and decreased salivary function

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Week 1: baseline disruption Most people begin GLP-1 therapy at the lowest available dose

But emerging research suggests these medicines also offer healthspanextending benefits for people without obesity or diabetes