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The move toward Phase III development matters because oral small-molecule GLP-1s could broaden adoption across obesity, type 2 diabetes and cardiometabolic risk populations where injectable therapies face adherence barriers

The drug reaches systemic circulation independently of food intake, and its receptor-binding activity remains intact regardless of what a person eats

And a lot of this stuff that weve looked at is just very, very substandard. Perrone writes for the Associated Press.

It accomplished this while simultaneously reducing pro-inflammatory cytokines IL-1beta and TNF-alpha and increasing the anti-inflammatory cytokine IL-10

Lincoff et al., 2023)