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Compared with standard paclitaxel, biologically interactive albumin-bound paclitaxel in solvent-free nanoparticles demonstrated greater efficacy and good safety [146]
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Quality and Purity Considerations: The safety of AOD-9604 depends significantly on the quality and purity of the peptide source
Toxicity/exposure ratios for birds, fish and aquatic invertebrates based on application rates of 2.5 kg a.i./ha of chlorothalonil to soybeans (worst case) Risk category LC 50 (mg/litre Estimated exposure Toxicity/exposure or mg/kg diet) (mg/litre or ratio (TER) c mg/kg diet) a,b Acute bird 4640 73.7-535.7 63.0-8.7 Acute fish (stream) 0.01 0.009-0.04 1.1-0.25 Acute fish (pond) 0.01 0.01 1.0 Acute aquatic invertebrate (stream) 0.07 0.009-0.04 7.8-1.8 Acute aquatic invertebrate (pond) 0.07 0.01 7.0 a Estimated environmental concentration in the terrestrial environment (for bird exposure) is based on the stated application rate and the assumption of deposition on short grass using the US EPA nomogram
