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SGLT2 inhibitors should generally be held 3 days before colonoscopy (4 days for ertugliflozin) due to diabetic ketoacidosis risk during fasting states, per FDA recommendations

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This author has long recognized the need for a shift of clinical focus from glycemic status to insulin homeostasis for detecting and optimally managing adverse metabolic, proinflammatory, endothelial, developmental, and neurologic effects of hyperinsulinism (ref

Creatine supplementation alongside tirzepatide requires increased water intake to prevent kidney strain and support creatine transport into muscles

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