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The reliability of DEGs was ensured through bio-function verification (such as KEGG pathway enrichment analysis) and metabolite association analysis

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Identified publications were reviewed for relevant data and were included in the review if appropriate

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However, Epitalon did not prolong the mean lifespan in all groups [84]

Last updated: March 22, 2026 Introduction to Inflammatory Bowel Disease The etiology of Inflammatory bowel disease (ulcerative colitis and Crohns disease) is complex, with genetic predisposition, an altered microbiome, environmental factors and a weakened epithelial (gut) barrier function triggering a chronic immune response in the mucosal layer