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Two trials of DPP-4 inhibitors, namely, Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR)Thrombolysis in Myocardial Infarction (TIMI) 53 and Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care in Patients with Type 2 Diabetes Mellitus and Acute Coronary Syndrome (EXAMINE), showed no increased risk of major adverse cardiovascular events [7, 8]

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In the REWIND study and AWARD5 study, dulaglutide consistently improved BP and lipid levels in patients [23, 38]