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To fully appreciate the clinical relevance of binding agents, we must first examine how complex chronic illnesses fundamentally disrupt the body's natural detoxification systems

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doi: 10.1158/1078-0432.CCR-14-1630 149 WeiXMaoLChiZShengXCuiCKongYet al

383,384,458,459 In this situation, targeting the metabolic symbiosis between cancer and stromal cells by inducing metabolic switching in the tumor TME leads to sensitization of targeted therapies

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