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Disclaimer: For optimal results, perform a patch test before first use

Transient headaches or lightheadedness during initial dosing

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A recent study including spontaneously hypertensive rats and controls (WKY) reported that UA therapy (16 mg/kg) induced Kruppel-like factor 2 (KLF2) expression, lowered vascular endothelial growth factor (VEGF)-A levels, reduced BBB leakage, and improved endothelial cell barrier integrity [194, 196]

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Hepatotoxicity is the greatest concern associated with APAP treatment