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A February 2026 Medscape panel discussion on managing constipation in GLP-1 patients, which included specialists from the Cleveland Clinic, identified bulk-forming fiber as a key strategy for patients experiencing constipation, alongside increased hydration, physical activity, and incorporating prebiotic and probiotic foods into the diet

McNabb et al., 1984

For all other indications, physicians must prescribe these medications off-label. To understand current physician prescribing practices of off-label GLP-1RA uses, Cure, a healthcare innovation ecosystem in New York City, in conjunction with the Deerfield Institute, a division of Deerfield Management Company, an affiliate of Cure, surveyed 122 physicians across the specialties of gastroenterology, addiction medicine, cardiology, neurology and orthopedics

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