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The SURPASS-2 trial (PubMed ID 34170647) reported greater HbA1c reductions with tirzepatide versus semaglutide 1 mg in type 2 diabetes cohorts, while SURMOUNT-1 (PubMed ID 35658024) documented substantial body-weight reductions versus placebo in obesity cohorts

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10.1152/japplphysiol.00869.2005 134 SmithG

There is no clinical evidence that orlistat speeds up the weight loss results of Wegovy