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Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H (2009) Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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Together, these two mechanisms explain why low-dose atropine can paradoxically enhance vagal effects and slow sinoatrial node firing before higher doses shift the balance toward the expected anticholinergic tachycardia