Several FXR agonists that have been assessed in clinical trials and their effects are: Obeticholic Acid (OCA): A derivative/synthetic variant of bile acid, it improves insulin sensitivity, liver inflammation, hepatocellular ballooning and reduces fibrosis (218)
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Mart MF, Pun BT, Pandharipande P, Jackson JC, Ely EW
Research has linked it to cardioprotective and neuroprotective effects
Collectively, these findings demonstrate that SLE is characterized by mTOR pathway hyperactivation and distinct T cell metabolic reprogramming favoring glycolysis and FAS, which disrupts Th17/Treg balance and drives autoimmunity, positioning metabolic intervention as a viable treatment strategy
Regeneration of Other Antioxidants : Glutathione can regenerate other antioxidants in the body, such as vitamins C and E, enhancing their effectiveness