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These cis-aconityl systems displayed same mechanism of action, where the amide bond is cleaved by carboxylic group in acidic environment
Commenting on the divergence between their results and those of the original June 2025 study by Hathaway et al., the authors of the present study point to a few differences in methodology
T2DM patients showed reduced activation in the right insula in response to palatable food compared to lean controls, and liraglutide increased the activation in the right insula and caudate nucleus at 10 days after treatment, but these effects were not observed after 12 weeks
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