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45,57 Itch was also able to bind to, ubiquitinate, and induce the proteasomal degradation of p73 via its second PR (proline-rich) region (aa 404487)

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The superoxide radical (O2) or singlet oxygen radical (1O2) generated in tissues through metabolism or reactions in cells is catalytically converted to hydrogen peroxide (H2O2) and molecular oxygen (O2) by superoxide dismutase (SOD)

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