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Alternate-day fasting: Alternating between days of normal eating and days of fasting

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Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a highly selective thyroid hormone receptor agonist in clinical trials for the treatment of dyslipidemia

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None of these is worthless, but none is a substitute for a prospective, adequately powered clinical trial, which is exactly what the program eventually ran

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N Engl J Med 1994;331:8425

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