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7.Knudsen LB, Lau J

Islets contain a glomerular-like network of fenestrated capillaries that comprise about 8-10% of islet volume

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Most skin reactions are mild and temporary

A subsequent randomized, double-blind, placebo-controlled trial in patients with BD ( n = 44) without comorbid type 2 diabetes mellitus (T2DM) or metabolic syndrome, demonstrated that adjunctive pioglitazone (1530 mg/day for 6 weeks) significantly improved depressive symptoms, measured using the Hamilton Depression Rating Scale (HAM-D), when added to lithium, without major adverse effects [56]