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GLP-1, or glucagon-like peptide-1 receptor agonists, act on the brain to influence feelings of satiety, for example, the more widely known brands include Ozempic and Mounjaro

It activates GLP-1 receptors located in the pancreas, brain, and digestive system

Schematic of the triple-receptor mechanism: GLP-1 (teal), GIP (blue) and glucagon (amber)

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When people first go on these medications they lose muscle and fat (which is natural), but if they go off of them and gain weight back, its all fat

Peripheral nerves do possess the capacity to regenerate, unlike central nervous system neurons, but the process is agonizingly slow, roughly one millimeter per day under optimal conditions, and existing medications do nothing to accelerate it