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GLP-1 medications are used to manage Type 2 diabetes and obesity by mimicking a hormone that regulates blood sugar levels and appetite

Similar changes in reduced activity of GST and GR were reported in susceptible mutants infected with TuMV (Otulak-Kozie et al., 2022b, 2023) after 7dpi which was associated with increased activity of GPXL in rbohD mutants (Otulak-Kozie et al., 2023)

Further studies and additional models are needed to clarify whether this reflects increased toxicity or immune activation

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[86] showed that the reduction of GPx-1 activity in silenced human endothelial cells for GPx1 expression accelerated oxidative stress and increased nuclear factor kappa-light-chain-enhancer of activated B cells (NFB) and c-Jun-N-terminal kinase (JNK) activation