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For patients using semaglutide for weight management, reduced potency simply means diminished therapeutic benefit rather than acute safety risks
Benefits include improved energy metabolism, enhanced insulin sensitivity, better mitochondrial function, and reduced age-associated weight gain
The latter problem could be explained by the presence of -fetoprotein, a circulating binding globulin found in late-gestation fetuses and early postnatal pups that has a high affinity for estradiol and thereby sequesters the steroid in the bloodstream, preventing it from masculinizing the brain
"They're not made for someone who is very, very slim and wants to get a little bit more fat off their body," she said
Some people with certain genetic variants maintain results longer
Rannem et al., 1998
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