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Meta-analyses show that semaglutide increases the likelihood of discontinuing treatment (relative risk 1.67, 95% CI 1.27-2.21), primarily due to gastrointestinal adverse events like nausea, vomiting, and diarrhea

But new research focusing specifically on people with bipolar is beginning to provide some answers

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Injectable GLP-1 medications have traditionally produced the strongest glucose-lowering effects

Clinical experience matters, especially for patients on complex medication regimens

Patients with a history of pancreatitis or kidney concerns are typically evaluated carefully by their provider before starting or continuing GLP-1 therapy