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LC3-II and Beclin-1 are key molecules in the autophagy pathway, induction of HO-1 activates the autophagy pathway by increasing the expression of LC3-II and Beclin-1, thereby removing harmful substances from cardiomyocytes [108]

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The possible use has been examined in laboratory and animal research in various physiological systems, such as musculoskeletal, gastrointestinal, and neurological tissues