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PMID: 35024317 Aggregate2025 Sep 1

It has become a biomarker associated with disease risk and health status

Penetration Enhancement Strategies The hydrophilic nature of GHK-Cu (log P approximately -2.3) limits passive diffusion through the lipophilic stratum corneum, necessitating penetration enhancement strategies for optimal topical delivery

Figure 5E reveals that the fluorescent intensity was reduced after H 2 O 2 treatment, while incubation with targeting peptide RGD-GHK recovered COL-1 expression

Larger randomised trials are needed before definitive clinical recommendations can be made.