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A few short years ago, these drugs were mainly prescribed for type 2 diabetes

Employing melatonin as an immunomodulatory agent therefore may require higher dosages to be effective, for example in murine models, a dose of 10mg/kg is widely used to investigate the anti-inflammatory and tissue-protective actions of melatonin (70)

[3] The major etiological factors best supported by the available evidence are inherited susceptibility, microbial infection, and environmental toxin exposure

Active site residues U46, E48, Q81, and W136 are highlighted and shown as sticks