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The potential association between psychiatric AEs and GLP-1 RAs was assessed by comparing the psychiatric AE reports for GLP-1 RAs with the complete FAERS database, performing a disproportionality analysis, and calculating the ROR

In comparison, the downregulated mRNAs in the tirzepatide group were predominantly enriched in signaling and cellular regulatory pathways, such as inflammatory mediator regulation of TRP channels, potentially reflecting a suppression of inflammatory activity

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3-hydroxykynurenine, 3-hydroxyanthranilic acid, and 5-hydroxyanthranilic acid are neurotoxic with ROS generation properties (75)