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Historical Background and Scientific Context Scientific interest in metabolic regulatory compounds has expanded significantly with advances in molecular biology and biochemical research

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These medications carry an FDA boxed warning for medullary thyroid carcinoma and are contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2

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Individuals with evidence of distal disease have a poor prognosis with 5-year survival estimates being 22% for distal nodal involvement and fall to 8% for patients with other identified visceral metastatic disease

George SR, ODowd BF, Lee SP