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MOTS-c is a mitochondrial-derived peptide that improves insulin sensitivity and metabolic flexibility at the cellular level

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The copper-peptide bond is thermodynamically unstable above 8C, and repeated thermal cycling (even brief excursions to 910C) causes cumulative damage

A serious systemic disturbance called metabolic acidosis can occur in CKD when acidic compounds, especially nitrogen-containing waste from dietary protein metabolism, accumulate in the blood

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Incretin-based therapies in MASLD/MASH: from GLP-1 receptor agonists to dual and triple agonists - mechanisms, clinical evidence, and therapeutic perspectives Hepatoma Res