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The SURPASS and SURMOUNT trials, which established tirzepatide's efficacy for diabetes and weight management respectively, allowed participants to inject at any time of day on their chosen injection day

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The thigh and upper arm are acceptable alternatives

Serious adverse events were uncommon in these trials, but rare outcomes and longer-term cardiovascular, renal, or oncologic risks require ongoing surveillance beyond trial lengths

Like any hormonal contraception, using the pill to stop periods isn't without potential drawbacks: Breakthrough bleeding

This result is consistent with the finding that cAMP signaling serves as the amplification pathway in pancreatic -cells