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Zepbound (tirzepatide) injection, for subcutaneous use: Highlights of prescribing information

GLP-1 has been tested as a regulator of anxiety behavior and both GLP-1 and exendin-4 (administered ip , into the lateral ventricle or intra-dorsal raphe) induced anxiety-like behavior, which was measured in the black and white box, elevated plus maze and open field tests in Spraque-Dawley rats [86]

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doi:10.1039/d1fo03180e

Insulin and sulfonylureas should be considered only as a last resort, as increased insulin levels may reactivate the PI3K pathway, counteracting the antitumor effects of PI3K inhibition (256,259)