As far as cellular health goes, supplementing reduced glutathione is a no-brainer
If you take a standard capsule, you are essentially just taking a very expensive amino acid supplement, as the "master antioxidant" itself is destroyed during digestion
NAC in very high doses (above 1800mg daily) can theoretically affect cysteine metabolism and insulin signalling, which may be relevant for diabetic patients on tirzepatide, but this is uncommon at standard supplementation levels
Individual results vary.
If you have Hashimotos hypothyroidism, this also means going on a strict gluten-free diet, as many studies show a connection between the autoimmune thyroid disease and a gluten intolerance or celiac disease
Key biomarkers include glutathione levels, malondialdehyde (MDA), 8-isoprostane, and C-reactive protein to establish baseline oxidative burden