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This pharmacological tolerance is one reason people start considering alternatives

The gut releases a hormone called GLP-1 into the bloodstream GLP-1 travels to the pancreas and brain where it attaches to special GLP-1 receptors Carbohydrates turn into glucose (sugar) and enter the bloodstream, raising blood sugar The pancreas releases insulin to help cells use this sugar for energy Extra sugar gets stored as glycogen for later use, or as fat if theres too much The pancreas also releases amylin which slows down digestion to prevent blood sugar from spiking too fast The GLP-1 receptors: Stimulates insulin production only when blood sugar is elevated Suppresses glucagon (hormone that raises blood sugar) when not needed Slows gastric emptying (digestion) to prevent blood sugar spikes Reduces appetite and creates feelings of fullness In people with diabetes, this whole system doesnt work properly, leading to blood sugar levels that stay too high for too long

MDPI, Chandwe, Kanta, and Paul Kelly

doi:10.1016/j.nutres.2011.01.002

(October 2016)

Jul 2017;8(4):587-596