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These medications slow gastric emptying and reduce appetite, which means patients often experience changes in their eating patterns, portion sizes, and food preferences

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A multivariable Cox proportional hazard regression model was performed to assess the association of GLP-1 RAs on HHF and all-cause death as hazard ratios (HRs) with 95% CI compared to the Other ADs group, stratifying by history of HF

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Epac activates the MAPK pathway, thereby promoting the activity of cyclin-dependent kinase 2 (CDK2) and CDK4, which in turn facilitate -cell differentiation and proliferation [35, 36] (Fig