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Tier: in vitro transcriptomics / computational

Thiazolidinedione (TZD) compounds, such as rosiglitazone (ROSI), pioglitazone (PIO), and troglitazone (TRO), reduced the mortality of mice after GPX4 was loss by inhibiting the action of ACSL4, indicating that these compounds may show potential therapeutic effects on AKI [43, 48]

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This is characterized by increased expression of pro-inflammatory genes (IL-1, IL-6 and TNF-) and decreased expression of anti-viral and antibody genes (e.g., IFNs) [71]

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