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They reported that histone proteins are lost in aging yeast cells, whereas histone protein overexpression and supplying extra histone proteins prolonged longevity 75

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Although DET1 preferentially interacts with Ube2e family members, Ube2d3 is likely recruited by RBX1 to catalyze polyubiquitination

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Reported side effects (rare): Mild fatigue Temporary nausea Injection site redness No known toxicity has been reported even at high doses in preclinical studies ( Toxicology Letters , 2022)