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Loss of bone mass is a concern, especially with getting fractures from falls, says Grunvald

For this analysis, off-label use was defined as absence of a diabetes diagnosis within the calendar year

Circulation 140 (12), 10041014

Indeed, GLP-1R knockout mice do not develop obesity [73] although postembryonic deletion of GLP-1Rs in the paraventricular nucleus of the hypothalamus (PVH) leads to weight gain due to increased food intake [72]

For each participant, this endpoint is defined as the ratio between the total weight loss achieved between the start of SURMOUNT-5 and the end of ATTAIN-MAINTAIN (week 52) over the total weight loss achieved between the start of SURMOUNT-5 and the baseline of ATTAIN-MAINTAIN (week 0)

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