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Oxidation of macromolecules is triggered by excess ROS, which in turn triggers cell death by releasing cytochrome c (Cyt-c) (82)

doi: 10.1039/C6MB00600K 187 ArmstrongCWMcGregorNRLewisDPButtHLGooleyPR

The pentose phosphate pathway generates NADPH from glucose, while mitochondrial enzymes produce NADPH to support glutathione recycling inside mitochondria [9]

J Biol Chem 279:5565955666 Zhao C, Wilson MC, Schuit F, Halestrap AP, Rutter GA (2001) Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas

IV glutathione is not safe

doi: 10.4172/2153-0645.1000141 149 KozlovE