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Studies like LEADER and SUSTAIN have shown reductions in major adverse cardiovascular events among high-risk patients with type 2 diabetes

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In 1986 , a truncated form of GLP-1 (specifically GLP-1(736) amide) was isolated from the gut and shown to have potent effects: it stimulated insulin secretion and suppressed glucagon secretion in the presence of elevated glucose ( [35] )

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But when total weight loss exceeds 20%, as it does in many GLP-1/GIP patients, that 25% lean mass fraction represents a significant absolute deficit in muscle tissue