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Several studies have shown that SDH-deficient cells exhibit increased tumorigenesis and that this increase is reversed by the addition of -KG, supporting the idea that succinate accumulation contributes to tumorigenesis through epigenetic modification 100

Many patients report this single change made the medication tolerable

Shukla SD, Hanahan DJ

KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma

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Lifestyle modifications include regular exercise (walking for 30 minutes, yoga, playing sports, or doing household activities)