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Kidney Protection and Brain Health A trial found semaglutide reduced kidney events by 24% in people with type 2 diabetes and chronic kidney disease using a lower dose, not the maximum. GLP-1s also strengthen the blood-brain barrier and enhance neuron survival, with early data hinting at benefits for cognitive decline and Alzheimer's disease. Systemic Anti-Inflammatory Effects GLP-1s reduce systemic inflammation throughout the body. This benefit doesn't get talked about much, though inflammation drives almost every chronic disease

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Neurology 68, 13051307

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Myth 3: GLP-1 Medications Cause Permanent Stomach Damage A common worry about GLP-1 medications is that they might cause lasting harm to your digestive system

First, this approach assesses the patients condition through quantitative clinical and biomarker scores rather than merely considering the presence or absence of MDD as a binary variable (thus, only one bit of information)