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Additionally, mast cell mediators can worsen edema, neuroinflammation, and neurotransmitter imbalance, intensifying the clinical picture

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The subcutaneous route allows for gradual absorption and distribution, which may help moderate peak concentrations and reduce acute toxicity compared to intravenous administration

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The largest study in humans is an exploratory analysis of the REWIND trial, evaluating the effect of dulaglutide vs