If you're in Washington with a BMI of 30 or higher, or 27 with a weight-related medical condition like hypertension, type 2 diabetes, or high cholesterol, you might be a candidate for semaglutide weight loss
Melmed S
This data does and the message is that the patients who probably need GLP-1s most (obese, knee-pain, can't easily exercise) are exactly the ones losing the most lean mass on the more potent option
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No direct trial exists in this population, the analogous functional-constipation literature is heterogeneous, and the most-marketed strain has both positive and null trials behind it
This doesnt mean it stops working entirely, but you might notice the effects wear off