MOTS-c has also garnered attention for possible benefits related to aging
however, studies suggest that a mechanism-based approach might offer an enhanced benefit in certain pain phenotypes
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Angiogenesis, NO Modulation & Cytokine Control BPC-157 activates angiogenesis to restore blood supply to damaged tissue, upregulates growth hormone receptors in tendons and muscles, modulates the nitric oxide system to reduce localized inflammation, stimulates fibroblast proliferation for collagen synthesis, and downregulates TNF- and IL-6 the primary cytokines driving chronic myofascial pain
So all of those changes conspire to put weight on
Whilst mechanistic rationale exists, clinical evidence remains limited and no UK guidance currently recommends allulose supplementation for patients receiving GLP-1 therapy