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Biomarker studies: establishing senescent cell burden diagnostic (e.g., imaging, blood markers) to monitor effect and guide dosing

the co-culture of MSCs and NP-cells increased the expression of anabolic GFs by MSCs, differentiation towards the discogenic lineage, and improvement of the NP cell phenotype through MSCs-NP cell communication, which was possibly mediated by the bi-directional intercellular transfer of membrane components [137,138]

The Enigma and challenges of Vitiligo Pathophysiology and treatment

As we age, our levels of stomach acid start to decline and these reduced levels can make it harder for B12 to be absorbed from food

Alternatively, continuous daily dosing for 12 weeks followed by a 4-week break is another common approach

Nuclei were Hoechst stained for 5 min