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Work with your provider to adjust medication dose or nutritional support if these occur

Third, the body composition narrative represents both a clinical imperative and a marketing opportunity

Received: Mar 24, 2025

Food loses some of its pull

The risk of worsening heart failure events alone dropped by 46% (HR 0.54)

In the run-in period, all patients, regardless of whether we are randomized to receive lira or placebo later, were subject to a hypocaloric diet and exercise regime, without GLP-1 receptor agonist, with the duration of the period for each patient being the time required to lose 5% of their baseline body weight In the STEP trials (Table 1), designed to evaluate the efficacy and safety of semaglutide 2.4mg (subcutaneous, weekly) in patients with obesity, or excess weight (BMI 27kg/m2) with complications, weight loss of between 15% and 17% was achieved 68 weeks after starting treatment.7678 In one of the trials, weight loss of 10% was reported after 20 weeks of therapy