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In diabetic rats, resveratrol doses corresponding to about 56 mg for an adult human normalized creatinine clearance (a measure of renal function), attenuated several markers of oxidative damage in kidney tissue, and improved levels of antioxidant enzymes and vitamins C and E (Palsamy 2011)

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425,426 SIRT3 deficiency impairs the mitochondrial membrane potential, induces ROS accumulation, and triggers NLRP3 inflammasome activation, exacerbating cardiac damage

The expression of cytochrome P450 initially increase with age from its low levels in neonatal stages, however, decrease in aged animals [13, 14]

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